Vaping may impair mucus clearance from airways: Study
PTI, Jun 7, 2019, 12:57 PM IST
Washington: Nicotine in e-cigarettes may hamper mucus clearance from the human airways, increasing the risk of infection and injury, according to a study.
The study, published in the American Journal of Respiratory and Critical Care Medicine, found that exposing human airway cells to e-cigarette vapour containing nicotine in culture resulted in a decreased ability to move mucus or phlegm across the surface.
This phenomenon is called “mucociliary dysfunction”.
Researchers from the University of Kansas, University of Miami and Mt Sinai Medical Center in the US report the same finding in vivo in sheep, whose airways mimic those of humans when exposed to e-cigarette vapour.
“This study grew out of our team’s research on the influence of tobacco smoke on mucus clearance from the airways,” said Matthias Salathe, a professor at the University of Kansas Medical Center.
“The question was whether vape containing nicotine had negative effects on the ability to clear secretions from the airways similar to tobacco smoke,” said Salathe.
Mucociliary dysfunction is a feature of many lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis.
The study found that vaping with nicotine impairs ciliary beat frequency, dehydrates airway fluid and makes mucus more viscous or sticky.
These changes make it more difficult for the bronchi, the main passageways to the lung, to defend themselves from infection and injury.
The researchers note that a recent report found that young e-cigarette users who never smoked were at increased risk of developing chronic bronchitis, a condition characterised by production of phlegm that is also seen in tobacco smokers.
Salathe said the newly published data not only supports the earlier clinical report, but helps explain it.
A single session of vaping can deliver more nicotine to the airways than smoking one cigarette, according to researchers.
Salathe said absorption into the bloodstream is lower, possibly exposing the airways to high nicotine concentrations for prolonged periods of time.
The study also found that nicotine produced these negative effects by stimulating the ion channel transient receptor potential ankyrin 1 (TRPA1).
Blocking TRPA1 reduced the effects of nicotine on clearance in both the human cells in culture and in the sheep.
“Vaping with nicotine is not harmless as commonly assumed by those who start vaping. At the very least, it increases the risk of chronic bronchitis,” Salathe said.
“Our study, along with others, might even question e-cigarettes as a harm reduction approach for current smokers with respect to chronic bronchitis/COPD,” said Salathe.
Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.
Top News
Related Articles More
Risk of abnormal blood fat levels increased by about 30 pc during pandemic, finds study
Attention problems could be ‘middleman’ between genetic risk for, experiencing psychosis: Study
Meeting WHO’s sodium recommendations could avert deaths from heart, kidney disease: Study
Meeting WHO’s sodium recommendations could avert deaths from heart, kidney disease: Study
Study finds loss of smell linked with inflammation in 140 conditions, could be early sign of disease
MUST WATCH
Latest Additions
Indian boxer Mandeep Jangra wins WBF’s world title
IOA submits ‘Letter of Intent’ to host 2036 Olympics in India
CBDT allows tax officials to waive or reduce interest due from assessee
Like UP, bring BJP to power in Jharkhand to ‘bulldoze’ mafia: Yogi at Koderma poll rally
Govt asks Wikipedia why it should not be treated as publisher instead of intermediary
Thanks for visiting Udayavani
You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.