Alzheimer’s: blood biomarker may help identify the disease ten years before symptoms start

PTI, Jan 19, 2023, 11:17 AM IST

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Though Alzheimer’s disease affects more than 55 million people worldwide, there’s still no cure for the condition – and treatment options are limited.

While recent advancements in the field have led to the development of two medications which may delay the progression of the disease, their benefits are debated. Not to mention that in most clinical trials looking at the effectiveness of these drugs, treatment only begins after symptoms arise. This means damage from the disease has already taken place.

It’s thought that if treatment is started earlier – before symptoms begin – this may prevent the damage from happening. But the problem is the clinical symptoms that doctors look for to diagnose a patient with Alzheimer’s disease only appear after neurodegeneration has taken place.

Our recent study argues for using a different biomarker than those currently used to diagnose Alzheimer’s. We found that this biomarker, which can be detected in a person’s blood, may allow the disease to be discovered up to ten years before symptoms start. This provides a window of opportunity for early treatment intervention.

Blood protein Our study was performed using data from Swedish families who had a form of Alzheimer’s disease caused by genetic mutations. While autosomal dominant Alzheimer’s disease (ADAD) has similar symptoms to sporadic Alzheimer’s disease (the most common form of Alzheimer’s, which is a combination of genetic, lifestyle and environmental factors), symptoms happen much earlier – typically in a person’s 40s or 50s.

Since the mutation is inherited, if a parent has ADAD their child will have a 50 per cent chance of inheriting the mutation. Although less than 1 per cent of all people with Alzheimer’s disease have this form, research studies in these families provide valuable information on how Alzheimer’s disease progresses in general.

Our study looked at 75 people from three different families who all had a history of ADAD. Participants provided 164 blood samples in total, all collected between 1994 and 2018. The levels for four different blood-based biomarkers with known links to Alzheimer’s disease were analysed. We also performed other tests to look for signs of the disease, such as MRI imaging and cognitive tests.

Our main finding was that levels of one particular protein, called GFAP, increased before other known disease-associated blood-based biomarkers analysed in the study. This increase had already begun ten years prior to the first noticeable signs of Alzheimer’s disease.

GFAP is a protein released by the brain’s astrocytes – specialised cells that take part in the brain’s immune system, among other functions. While we know that GFAP is involved in the brain’s immune system processes, we don’t know its exact function. In studies on other forms of Alzheimer’s disease, GFAP has been suggested to mirror the activity of brain inflammation. It’s also associated with the presence of amyloid plaques – a hallmark of Alzheimer’s disease.

Our results are in line with other recent studies on genetic forms of Alzheimer’s, which have shown higher GFAP levels before disease onset.

Research has also shown that GFAP levels are higher in people with preclinical Alzheimer’s disease without a genetic cause, who have other signs of Alzheimer’s pathology (such as amyloid plaques) but aren’t yet exhibiting symptoms. This suggests that our findings may also apply to the more common, sporadic forms of Alzheimer’s disease.

The results of our study are also important for supporting our general understanding of Alzheimer’s disease – particularly the early disease processes in the brain. Together with other recent findings, it’s clear that further investigation is needed to understand more about GFAP and its function in the brain – including in the progression of Alzheimer’s disease.

Perhaps future treatments for Alzheimer’s disease will be more successful if they seek to target both the brain’s astrocytes and other common hallmarks of Alzheimer’s disease – such as the accumulation of the beta-amyloid in the brain.