Covaxin booster dose enhances vaccine effectiveness against Delta, Omicron variants, says ICMR study


PTI, Jun 15, 2022, 2:07 PM IST

 

New Delhi: The administration of Covaxin as a booster dose enhances vaccine effectiveness against COVID-19’s Delta variant and gives protection against Omicron variants BA.1.1 and BA.2, a study by ICMR and Bharat Biotech has found.

The protective efficacy of Bharat Biotech’s Covaxin following two and three-dose immunisations against the Delta variant and the efficacy of the Covaxin against Omicron variants were studied in a Syrian hamster model (animal model to study human-associated diseases), it said.

The antibody response, clinical observations, viral load reduction and lung disease severity after virus challenge were observed, it added.

The findings of the study have been published on Tuesday on bioRxiv, a pre-print server and have not been peer reviewed.

“In the Delta infection study, where we compared the protective response between the two and three-dose regimens, we could observe the advantage of the booster dose vaccination in the protection. Although the neutralising antibody levels were comparable among the groups, lung disease severity was found more reduced after the three dose vaccination.

“The virus shedding and viral organ load were considerably reduced in both the two dose and three-dose immunised animals indicating the vaccine efficacy against Delta variant,” the study by Indian Council of Medical Research and Bharat Biotech said.

In the second study in which the protective response was assessed against Omicron variants i.e. BA.1 and BA.2, following three-dose vaccinations, lesser virus shedding, lung viral load and lung disease severity were observed in the immunised groups in comparison to the placebo groups.

“The evidence from the present study shows that Covaxin booster immunisation tends to broaden the protective immune response and reduces disease severity against the Delta and Omicron variant infection,” it further said.

Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.

Top News

Rohit Bal: The Valley boy who strode to great heights in fashion

Jaishankar to visit Australia, Singapore from Nov 3-8

Kadaba: Scooter rider’s death in tree fall – Public protests, demands removal of hazardous trees

Bantwal: Old video of elderly woman bursting firecrackers in hand goes viral

3rd Test: India strike early after taking slender lead against New Zealand at tea on day 2

M’luru: Rajasthan Duo busted in Amazon order scam; goods worth Rs. 11.45 Lakh seized

BJP to hold statewide protest against alleged land seizure by Waqf board

Related Articles More

Attention problems could be ‘middleman’ between genetic risk for, experiencing psychosis: Study

Meeting WHO’s sodium recommendations could avert deaths from heart, kidney disease: Study

Meeting WHO’s sodium recommendations could avert deaths from heart, kidney disease: Study

Study finds loss of smell linked with inflammation in 140 conditions, could be early sign of disease

Manipal Centre for Biotherapeutics Research hosts “Cell Therapy Conclave” at Kasturba Medical College, Manipal

MUST WATCH

Gho Pooja in Deepavali Festival

Melukote Deepavali

Ganapathi Co-operative Society Ltd

Udayavani Chinnara Banna 2024

Annapoorna Aahar | Food Places In Mysore


Latest Additions

Kejriwal promises to waive inflated water, electricity bills if AAP returns to power in Delhi

Rohit Bal: The Valley boy who strode to great heights in fashion

Jaishankar to visit Australia, Singapore from Nov 3-8

Kadaba: Scooter rider’s death in tree fall – Public protests, demands removal of hazardous trees

Bantwal: Old video of elderly woman bursting firecrackers in hand goes viral

Thanks for visiting Udayavani

You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.