COVID-19 reinfection casts doubt on virus immunity: Study
PTI, Oct 13, 2020, 12:13 PM IST
Paris: Covid-19 patients may experience more severe symptoms the second time they are infected, according to research released Tuesday confirming it is possible to catch the potentially deadly disease more than once.
A study published in The Lancet Infectious Diseases journal charts the first confirmed case of Covid-19 reinfection in the United States — the country worst hit by the pandemic — and indicates that exposure to the virus may not guarantee future immunity.
The patient, a 25-year-old Nevada man, was infected with two distinct variants of SARS-CoV-2, the virus that causes Covid-19, within a 48-day time frame.
The second infection was more severe than the first, resulting in the patient being hospitalised with oxygen support.
The paper noted four other cases of reinfection confirmed globally, with one patient each in Belgium, the Netherlands, Hong Kong and Ecuador.
Experts said the prospect of reinfection could have a profound impact on how the world battles through the pandemic.
In particular, it could influence the hunt for a vaccine — the currently Holy Grail of pharmaceutical research.
“The possibility of reinfections could have significant implications for our understanding of Covid-19 immunity, especially in the absence of an effective vaccine,” said Mark Pandori, for the Nevada State Public Health Laboratory and lead study author.
“We need more research to understand how long immunity may last for people exposed to SARS-CoV-2 and why some of these second infections, while rare, are presenting as more severe.”
Waning immunity?
Vaccines work by triggering the body’s natural immune response to a certain pathogen, arming it with antibodies it to fight off future waves of infection.
But it is not at all clear how long Covid-19 antibodies last.
For some diseases, such as measles, infection confers lifelong immunity. For other pathogens, immunity may be fleeting at best.
The authors said the US patient could have been exposed to a very high dose of the virus the second time around, triggering a more acute reaction.
Alternatively, it may have been a more virulent strain of the virus.
Another hypothesis is a mechanism known as antibody dependent enhancement — that is, when antibodies actually make subsequent infections worse, such as with dengue fever.
The researchers pointed out that reinfection of any kind remains rare, with only a handful of confirmed cases out of tens of millions of Covid-19 infections globally.
However, since many cases are asymptomatic and therefore unlikely to have tested positive initially, it may be impossible to know if a given Covid-19 case is the first or second infection.
In a linked comment to The Lancet paper, Akiko Iwasaka, a professor of Immunobiology and Molecular, Cellular and Developmental Biology at Yale University, said the findings could impact public health measures.
“As more cases of reinfection surface, the scientific community will have the opportunity to understand better the correlates of protection and how frequently natural infections with SARS-CoV-2 induce that level of immunity,” she said.
“This information is key to understanding which vaccines are capable of crossing that threshold to confer individual and herd immunity,” added Iwasaka, who was not involved in the study.
Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.
Top News
Related Articles More
BTS2024: If India can make rocket sensors, it can also make car sensors, says ISRO chief Somanath
World COPD Day: Know your lung function
SpaceX successfully launches ISRO’s 4,700 kg communication satellite from US
As AI and megaplatforms take over, the hyperlinks that built the web may face extinction
Plastic waste could double by 2050, researchers find, suggest policies to address issue
MUST WATCH
Latest Additions
Air pollution: SC flags Delhi govt’s failure to implement GRAP-4 curbs on entry of trucks
Drugs worth Rs 6 crore seized in Bengaluru, five arrested
Siddaramaiah urges Nirmala Sitharaman to address NABARD’s loan cuts to farmers
Satwik-Chirag enter semifinals, Lakshya loses to Antonsen in China Masters
BJP stages protest against Congress govt in Karnataka over Waqf properties row
Thanks for visiting Udayavani
You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.