Health Ministry adds steroid dexamethasone in COVID-19 treatment protocol
PTI, Jun 27, 2020, 3:20 PM IST
New Delhi: An inexpensive, widely used steroid dexamethasone was included in the treatment protocols for COVID-19 patients in moderate to severe stages of illness among other therapeutic measures by the Union health ministry on Saturday.
The updated protocol includes the advice to use dexamethasone as an alternative choice to methylprednisolone for managing moderate to severe cases of COVID-19. The change has been made after considering the latest available evidence and expert consultation, the ministry said.
According to the revised ‘Clinical Management Protocols for COVID-19’, dexamethasone which is already used in treating lung infections besides in a wide range of conditions for its anti-inflammatory and immunosuppressant effects can be used as an alternative to methylprednisolone which already existed in the treatment guidelines.
The health ministry on June 13 had also allowed the use of antiviral drug remdesivir for restricted emergency use and off-label application of tocilizumab, a drug that modifies the immune system or its functioning, and convalescent plasma for treating COVID-19 patients in the moderate stage of the illness as an “investigational therapy”.
It also recommended hydroxychloroquine in patients during the early course of the disease and not on critically ill patients.
The use of these drugs continues to be included in the revised treatment protocols under the ‘investigational therapy’.
The revised treatment protocols for moderate cases advised considering methylprednisolone 0.5 to 1 mg/kg or dexamethasone 0.1 to 0.2 mg/kg for three days, preferably within 48 hours of admission or if oxygen requirement is increasing and if inflammatory markers are increased. The duration of administration should be reviewed as per the clinical response.
For patients having respiratory distress requiring mechanical ventilation, both non- invasive and invasive, the ministry said methylprednisolone 1 – 2mg/kg/day or dexamethasone 0.2 to 0.4 mg/kg per day should be considered for 5-7 days in two divided doses, if not given already.
“Note that a larger dose of glucocorticoid will delay the removal of coronavirus due to immunosuppressive effects,” the treatment protocols stated.
The revised treatment protocols were issued as India’s COVID-19 tally raced past the five-lakh mark on Saturday with the biggest single-day surge of 18,552 cases while the death toll climbed to 15,685 with 384 fatalities, the updated figure at 8 am showed.
According to WHO, the corticosteroid dexamethasone was tested in hospitalized patients with COVID-19 in the United Kingdom’s national clinical trial ‘RECOVERY’ and was found to have benefits for critically ill patients.
According to preliminary findings shared with WHO, for patients on ventilators, the treatment was shown to reduce mortality by about one-third, and for patients requiring only oxygen, mortality was cut by about one-fifth.
Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.
Top News
Related Articles More
15-year-old girl raped by school teacher in Rajasthan’s Sikar: Police
3 killed, 6 injured as truck crushes people sleeping on footpath in Pune
Ambedkar row: Congress to hold nationwide protest against Amit Shah’s remarks
Notorious gangster wanted in UAPA case arrested at Nepal border
‘Condition critical’, say doctors as farmer leader Dallewal’s fast enters 27th day
MUST WATCH
Latest Additions
Man arrested for posing as Lokayukta official
‘Govt plotting fake encounter against C.T. Ravi’, alleges Union Minister Prahlad Joshi
15-year-old girl raped by school teacher in Rajasthan’s Sikar: Police
3 killed, 6 injured as truck crushes people sleeping on footpath in Pune
Perla Fire Disaster: Five shops completely gutted; Loss estimated at Rs 1.83 crore
Thanks for visiting Udayavani
You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.