Symptom and viral rebound rare after untreated COVID-19 infection: Study
PTI, Feb 21, 2023, 1:15 PM IST
Credit: iStock Photo
A combination of symptom and viral rebound after untreated COVID-19 infection is rare, occurring in only three per cent of study participants, an analysis of a COVID-19 trial has found.
Widespread use of nirmatrelvir — a recommended treatment for outpatients with mild to moderate COVID-19 — has been accompanied by reports of worsening symptoms and virologic rebound after treatment completion, the researchers said.
Virologic rebound has also been reported in persons who did not receive nirmatrelvir therapy, they said.
However, studies that can define the frequencies of symptom and viral rebound during the natural course of COVID-19 are lacking.
Researchers from Brigham and Women’s Hospital in the US conducted an analysis of 563 participants receiving placebo in a trial.
The study, published in the journal Annals of Internal Medicine, found that a combination of symptom and high-level viral rebound occurred in only three per cent of participants.
Symptom rebound alone occurred in 26 per cent of participants 11 days after initial symptom onset and viral rebound alone occurred in 31 per cent of participants, the researchers said.
High-level viral rebound was observed in 13 per cent of participants, they said.
The researchers noted that both symptom and viral rebound were short, lasting only one day in most participants.
These results highlight the importance of accounting for underlying rates of symptom relapse in the absence of antiviral therapy when evaluating the effects of antiviral treatments, they added.
Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.
Top News
Related Articles More
Attention problems could be ‘middleman’ between genetic risk for, experiencing psychosis: Study
Meeting WHO’s sodium recommendations could avert deaths from heart, kidney disease: Study
Meeting WHO’s sodium recommendations could avert deaths from heart, kidney disease: Study
Study finds loss of smell linked with inflammation in 140 conditions, could be early sign of disease
Manipal Centre for Biotherapeutics Research hosts “Cell Therapy Conclave” at Kasturba Medical College, Manipal
MUST WATCH
Latest Additions
Jayant Patil claims BJP used irrigation ‘scam’ to blackmail Ajit Pawar; Fadnavis, NCP chief hit back
Medical College expels 5 MBBS students from hostel for ragging juniors
Insulting women is in DNA of Cong leaders, alleges Jharkhand BJP
Man arrested from Delhi for calling up Pappu Yadav posing as aide of Lawrence Bishnoi
Tejasvi Surya hits out at Kharge, CMs of Cong-ruled states over poll promises
Thanks for visiting Udayavani
You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.