Symptom and viral rebound rare after untreated COVID-19 infection: Study


PTI, Feb 21, 2023, 1:15 PM IST

Credit: iStock Photo

A combination of symptom and viral rebound after untreated COVID-19 infection is rare, occurring in only three per cent of study participants, an analysis of a COVID-19 trial has found.

Widespread use of nirmatrelvir — a recommended treatment for outpatients with mild to moderate COVID-19 — has been accompanied by reports of worsening symptoms and virologic rebound after treatment completion, the researchers said.

Virologic rebound has also been reported in persons who did not receive nirmatrelvir therapy, they said.

However, studies that can define the frequencies of symptom and viral rebound during the natural course of COVID-19 are lacking.

Researchers from Brigham and Women’s Hospital in the US conducted an analysis of 563 participants receiving placebo in a trial.

The study, published in the journal Annals of Internal Medicine, found that a combination of symptom and high-level viral rebound occurred in only three per cent of participants.

Symptom rebound alone occurred in 26 per cent of participants 11 days after initial symptom onset and viral rebound alone occurred in 31 per cent of participants, the researchers said.

High-level viral rebound was observed in 13 per cent of participants, they said.

The researchers noted that both symptom and viral rebound were short, lasting only one day in most participants.

These results highlight the importance of accounting for underlying rates of symptom relapse in the absence of antiviral therapy when evaluating the effects of antiviral treatments, they added.

Udayavani is now on Telegram. Click here to join our channel and stay updated with the latest news.

Top News

Youth attempts suicide after being humiliated in public for wearing ripped jeans in Belthangady

India crawl to 51 for 4 after losing top-order

Nursing student suicide: Three students arrested in Kerala

Nadda’s letter to Kharge full of falsehoods: Cong

10 month baby gets new heart, new life

Actress Kasthuri released from jail, says ‘I thank those who made me raging storm’

Kidnapped for ransom in 1998, 26/11 survivor Gautam Adani faces biggest trial

Related Articles More

10 month baby gets new heart, new life

World COPD Day: Know your lung function

As Delhi chokes with dangerous pollution levels, doctors warn of health risks for all

World Diabetes Day 2024: Kasturba Hospital Manipal Hosts Zumba Session at Malpe Beach to Raise Diabetes Awareness

World Diabetes Day: An overview of types of diabetes

MUST WATCH

Christmas Cake Fruit Mixing

DK Shivakumar

Rose Cultivation

Geethotsava

Naxal Operation


Latest Additions

US charges against Adani, 7 others could lead to arrest warrants, extradition bid: attorney

Youth attempts suicide after being humiliated in public for wearing ripped jeans in Belthangady

Baku climate talks: The ‘X’ factor that could determine future of Global South

Kerala HC denies bail to police officer accused of ‘raping’ minor Dalit girl

Global Bhagavad Gita Quiz Announced: Registration now open

Thanks for visiting Udayavani

You seem to have an Ad Blocker on.
To continue reading, please turn it off or whitelist Udayavani.